Evaluating the incremental value of new biomarkers with integrated discrimination improvement.

Practice of Epidemiology Evaluating the Incremental Value of New Biomarkers With Integrated Discrimination Improvement

The integrated discrimination improvement (IDI) index is a popular tool for evaluating the capacity of a marker to predict a binary outcome of interest. Recent reports have proposed that the IDI is more sensitive than other metrics for identifying useful predictive markers. In this article, the authors use simulated data sets and theoretical analysis to investigate the statistical properties of...

Net reclassification improvement and integrated discrimination improvement: new standards for evaluating the incremental value of stress imaging for risk assessment.

Quantifying the value of biomarkers for predicting mortality.

PURPOSE In light of widespread interest in the prognostic value of biomarkers, we apply three discrimination measures to evaluate the incremental value of biomarkers--beyond self-reported measures--for predicting all-cause mortality. We assess whether all three measures--area under the receiver-operating characteristic curve, continuous net reclassification improvement, and integrated discrimin...

Prognostic value of biomarkers in heart failure: application of novel methods in the community.

BACKGROUND Mortality among patients with heart failure is high. Though individual biomarkers have been investigated to determine their value in mortality risk prediction, the role of a multimarker strategy requires further evaluation. METHODS AND RESULTS Olmsted County residents presenting with heart failure from July 2004 to September 2007 were recruited to undergo biomarker measurement. We ...

Comparison of Bayesian and Frequentist Methods in Estimating the Net Reclassification and Integrated Discrimination Improvement Indices for Evaluation of Prediction Models: Tehran Lipid and Glucose Study

Introduction: The Frequency-based method is commonly used to estimate the Net Reclassification Improvement (NRI)- and Integrated Discrimination Improvement (IDI) indices. These indices measure the magnitude of the performance of statistical models when a new biomarker is added. This method has poor performance in some cases, especially in small samples. In this study, the performance of two Bay...